The following areas are needed in drug discovery:

⸰Enzymology ⸰Pharmacology ⸰Cellular Biology ⸰Molecular Genetics ⸰Virology ⸰Mathematics ⸰Statistics ⸰Protein Crystallography

⸰Analytical Chemistry ⸰Organic Chemistry ⸰Mammalian Toxicology

What skills are in high demand?

⸰Computational Skills, e.g. coding, searching databases, solving X Ray data

⸰High willingness to learn across discipline

⸰Genetic engineering

We will touch upon many of these areas with emphasis on HIV patients who had previously been treated on existing therapy(s).

A biphenyl ether template afforded a robust range of patentable structures. This talk will focus on the synthesis of these molecules. We will also address the inhibition of multiple RT mutants and their accompanying antiviral activity. If time allows, the lead structures possessed poor aqueous solubility that were modified to lead drug candidates.